The labs of SynthImmune PIs Oliver Fackler and Petr Chlanda have published a paper in the journal Nature Communications entitled “A tissue-intrinsic mechanism sensitizes HIV-1 particles for TLR-triggered innate immune responses”.
In it, the authors demonstrate that previously observed environmental restriction to cell-free virus infectivity imposed by collagen-rich 3D extracellular matrix is mediated by adhesive ECM components assembled into tissue-like scaffolds. Their work identifies the biophysical properties of the ECM as a tissue-intrinsic arm of antiviral innate immunity.
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