2026
Genetic encoding and mutagenesis of RNA droplet phenotypes
William Verstraeten, Mai P. Tran, Alena Taskina, Pranay Jaiswal, Ivar S. Haugerud, Claudia Helbig, Moritz Hamberger, Edward W. Green, Michael Platten, Christoph A. Weber & Kerstin Göpfrich
Nat Chem Eng (2026). https://doi.org/10.1038/s44286-026-00454-4
William Verstraeten, Mai P. Tran, Alena Taskina, Pranay Jaiswal, Ivar S. Haugerud, Claudia Helbig, Moritz Hamberger, Edward W. Green, Michael Platten, Christoph A. Weber & Kerstin Göpfrich
Nat Chem Eng (2026). https://doi.org/10.1038/s44286-026-00454-4
Inhibition of CDK12/CDK13-CYCLIN K rewires P-TEFb signaling to reverse HIV-1 latency and modulate cellular gene expression
Praveenkumar Murugavelu, Jagrity Rani, Heli Glebko, Ina Ambiel, Nadine Tibroni, Nili Tickotsky, Ferdinand Heyn, Philipp Schommers, Liron Levin, Alona Kuzmina, Oliver Till Fackler & Ran Taube
EMBO Mol Med (2026). https://doi.org/10.1038/s44321-026-00536-z
Praveenkumar Murugavelu, Jagrity Rani, Heli Glebko, Ina Ambiel, Nadine Tibroni, Nili Tickotsky, Ferdinand Heyn, Philipp Schommers, Liron Levin, Alona Kuzmina, Oliver Till Fackler & Ran Taube
EMBO Mol Med (2026). https://doi.org/10.1038/s44321-026-00536-z
Co-expression of non-signaling CARs enhances EGFRvIII-specific CAR T-cell cytotoxicity against head and neck squamous cell carcinoma
Kathleen Grueter, Nicole Sander, Luisa Coen, Saskia Hüsken, Eileen Kleinfelder, Corinna Haist, Franziska Blaeschke, Kathrin Scheckenbach, Cornelia Monzel, Helmut Hanenberg & Constanze Wiek
BMC Cancer 26, 1149 (2026). https://doi.org/10.1186/s12885-026-17058-z
Kathleen Grueter, Nicole Sander, Luisa Coen, Saskia Hüsken, Eileen Kleinfelder, Corinna Haist, Franziska Blaeschke, Kathrin Scheckenbach, Cornelia Monzel, Helmut Hanenberg & Constanze Wiek
BMC Cancer 26, 1149 (2026). https://doi.org/10.1186/s12885-026-17058-z
UELer: a Jupyter-based framework for interactive exploration of multiplexed imaging datasets
Yu-Le Wu, Chun-Shan Liu, Bénédicte Lenoir, Kilian Merz, Michael T. Dill, Felix J. Hartmann
bioRxiv 2026.08.21.745700; doi: https://doi.org/10.64898/2026.08.21.745700
Yu-Le Wu, Chun-Shan Liu, Bénédicte Lenoir, Kilian Merz, Michael T. Dill, Felix J. Hartmann
bioRxiv 2026.08.21.745700; doi: https://doi.org/10.64898/2026.08.21.745700
Dynamic Covalent Functionalization of DNA Origami via Iminoboronate Chemistry
Alejandro Postigo, Enrique Guerreiro, Joseba Ruiz, M. Sofía Navarrete-Burgos, William Verstraeten, Kerstin Göpfrich, Silvia Hernández-Ainsa, Jesús del Barrio
Journal American Chemical Society 19 August 2026; 148 (32): 34033–34037. https://doi.org/10.1021/jacs.6c08320
Alejandro Postigo, Enrique Guerreiro, Joseba Ruiz, M. Sofía Navarrete-Burgos, William Verstraeten, Kerstin Göpfrich, Silvia Hernández-Ainsa, Jesús del Barrio
Journal American Chemical Society 19 August 2026; 148 (32): 34033–34037. https://doi.org/10.1021/jacs.6c08320
Latent effector T cells mediate immunotherapy responses in the bone marrow microenvironment
Niklas Kehl, Tim R. Wagner, Simon Steiger, Tamara Boschert, Michael Kilian, Antonia Schach, Julius J. Michel, Kane Foster, Gabrielle M. Hernandez, Claudia Ctortecka, Anna D. Metzler, Alanna Kirschner, Arne Van der Vreken, Dominik Humer, René Onken, Sven Cuntz, Julian Zoller, Cornelius Funk, Selina Neunhäuser, Maximilian Mönnig, Bruno Schönfelder, Simon Renders, Claudia Maldonado Torres, Lilli S. Sester, Jan H. Frenking, Franziska Werner, Wolfram Osen, Katharina Lindner, Ezgi Sen, Sabrina Schumacher, Daria Galas-Filipowicz, Evie Fitzsimons, Edward W. Green, Patrick Schmidt, John M. Lindner, Sebastian Uhrig, Lukas Bunse, Benny Chain, Hartmut Goldschmidt, Niels Weinhold, Stefan Fröhling, Tim Sauer, Simon Raffel, Jennifer G. Abelin, Steven A. Carr, Kwee Yong, Andreas Trumpp, Carsten Müller-Tidow, Karsten Rippe, Marc S. Raab, Michael Platten, Stefan B. Eichmüller, Mirco J. Friedrich
Cancer Cell, 2026; 0; https://doi.org/10.1016/j.ccell.2026.07.011
Niklas Kehl, Tim R. Wagner, Simon Steiger, Tamara Boschert, Michael Kilian, Antonia Schach, Julius J. Michel, Kane Foster, Gabrielle M. Hernandez, Claudia Ctortecka, Anna D. Metzler, Alanna Kirschner, Arne Van der Vreken, Dominik Humer, René Onken, Sven Cuntz, Julian Zoller, Cornelius Funk, Selina Neunhäuser, Maximilian Mönnig, Bruno Schönfelder, Simon Renders, Claudia Maldonado Torres, Lilli S. Sester, Jan H. Frenking, Franziska Werner, Wolfram Osen, Katharina Lindner, Ezgi Sen, Sabrina Schumacher, Daria Galas-Filipowicz, Evie Fitzsimons, Edward W. Green, Patrick Schmidt, John M. Lindner, Sebastian Uhrig, Lukas Bunse, Benny Chain, Hartmut Goldschmidt, Niels Weinhold, Stefan Fröhling, Tim Sauer, Simon Raffel, Jennifer G. Abelin, Steven A. Carr, Kwee Yong, Andreas Trumpp, Carsten Müller-Tidow, Karsten Rippe, Marc S. Raab, Michael Platten, Stefan B. Eichmüller, Mirco J. Friedrich
Cancer Cell, 2026; 0; https://doi.org/10.1016/j.ccell.2026.07.011
FGFR2 fusion-driven cholangiocarcinoma is characterized by a distinct neutrophil-enriched tumor microenvironment in a syngeneic murine model
Nugzar Lekiashvili, Trinh Kieu Dinh, Alexander Olkus, Yu-Le Wu 6 Chun-Shan Liu, Daria Komkova, Albrecht Stenzinger, Felix J. Hartmann, Thomas Longerich, Michael T. Dill
JHEP Reports (2026); https://doi.org/10.1016/j.jhepr.2026.101964
Nugzar Lekiashvili, Trinh Kieu Dinh, Alexander Olkus, Yu-Le Wu 6 Chun-Shan Liu, Daria Komkova, Albrecht Stenzinger, Felix J. Hartmann, Thomas Longerich, Michael T. Dill
JHEP Reports (2026); https://doi.org/10.1016/j.jhepr.2026.101964
Peptide Thioester and Triazole Derivatives Through On-Resin Dual-Modification of Peptide Thiosulfonates
Marius Werner, Agnes Bergmann, Chenxi Liu, Mira Behnam, Christian Klein, Franziska Thomas
Angewandte Chemie International Edition (2026): e8315692, https://doi.org/10.1002/anie.8315692
Marius Werner, Agnes Bergmann, Chenxi Liu, Mira Behnam, Christian Klein, Franziska Thomas
Angewandte Chemie International Edition (2026): e8315692, https://doi.org/10.1002/anie.8315692
Extracellular ATP-P2RY2 signaling drives intratumoral prostaglandin E2 accumulation and adaptive resistance to immunotherapy in solid tumors
Zhaoqing Hu, Hitoshi Matsuo, Shangce Du, Cecilia Berzain Battioni, Lena Jassowicz, Rafael Carretero, Melanie Sator-Schmitt, Xiyue Zhao, Beiping Miao, Cansu Eris, Helena Engel, Mohamed A.A. Mahmoud, Elke Laport, Yanling Xiao, Ilse Hofmann, Christel Herold-Mende, Chong Sun
Immunity (2026); 0. https://doi.org/10.1016/j.immuni.2026.06.006
Zhaoqing Hu, Hitoshi Matsuo, Shangce Du, Cecilia Berzain Battioni, Lena Jassowicz, Rafael Carretero, Melanie Sator-Schmitt, Xiyue Zhao, Beiping Miao, Cansu Eris, Helena Engel, Mohamed A.A. Mahmoud, Elke Laport, Yanling Xiao, Ilse Hofmann, Christel Herold-Mende, Chong Sun
Immunity (2026); 0. https://doi.org/10.1016/j.immuni.2026.06.006
IDH1-mutant vaccine in newly diagnosed astrocytoma: final analysis of the multicenter, single-arm, open-label, first-in-human phase 1 NOA16 trial
Lukas Bunse, Katharina Lindner, Antje Wick, Angelika Freitag, Lisa-Marie Lanz, Dominic Edelmann, Abigail Suwala, Michael O. Breckwoldt, Inga Harting, Felix Sahm, Richard F. Schlenk, Anita Schmitt, Oliver Schnell, Jörg Hense, Martin Misch, Dietmar Krex, Monika Denk, Juliane Walz, Joachim P. Steinbach, Andreas von Deimling, Michael Schmitt, Theresa Bunse, Ghazaleh Tabatabai, Martin Bendszus, Isabel Poschke, Wolfgang Wick & Michael Platten
Nat Cancer (2026). https://doi.org/10.1038/s43018-026-01199-y
Lukas Bunse, Katharina Lindner, Antje Wick, Angelika Freitag, Lisa-Marie Lanz, Dominic Edelmann, Abigail Suwala, Michael O. Breckwoldt, Inga Harting, Felix Sahm, Richard F. Schlenk, Anita Schmitt, Oliver Schnell, Jörg Hense, Martin Misch, Dietmar Krex, Monika Denk, Juliane Walz, Joachim P. Steinbach, Andreas von Deimling, Michael Schmitt, Theresa Bunse, Ghazaleh Tabatabai, Martin Bendszus, Isabel Poschke, Wolfgang Wick & Michael Platten
Nat Cancer (2026). https://doi.org/10.1038/s43018-026-01199-y
Stress granule phase separation in stress-responsive cytosolic extract-in-oil droplets
Aline Lieber, Oskar Staufer, Zhaozhi Sun, Ulrike Engel, Charlotte Flory, Nathan Mikhaylenko, Kevin Jahnke, Katja Kopp, Philipp Klein, Sarah Hofmann, Oliver T. Fackler, Pavel Ivanov, Ilia Platzman, Pietro Scaturro, Joachim P. Spatz & Alessia Ruggieri
Nat Commun 17, 5011 (2026). https://doi.org/10.1038/s41467-026-73936-x
Aline Lieber, Oskar Staufer, Zhaozhi Sun, Ulrike Engel, Charlotte Flory, Nathan Mikhaylenko, Kevin Jahnke, Katja Kopp, Philipp Klein, Sarah Hofmann, Oliver T. Fackler, Pavel Ivanov, Ilia Platzman, Pietro Scaturro, Joachim P. Spatz & Alessia Ruggieri
Nat Commun 17, 5011 (2026). https://doi.org/10.1038/s41467-026-73936-x
Late-Stage Functionalization of Peptides on the Solid Phase
Marius Werner, Truc Lam Pham, Franziska Thomas
Angewandte Chemie International Edition (2026): e4556652, https://doi.org/10.1002/anie.4556652
Marius Werner, Truc Lam Pham, Franziska Thomas
Angewandte Chemie International Edition (2026): e4556652, https://doi.org/10.1002/anie.4556652
DNA origami-based virus-like particles: a new class of HIV vaccine candidates with superior immunogenic properties
Frauke Muecksch, Juan Hamdan & Oliver T. Fackler
Sig Transduct Target Ther 11, 193 (2026). https://doi.org/10.1038/s41392-026-02735-z
Frauke Muecksch, Juan Hamdan & Oliver T. Fackler
Sig Transduct Target Ther 11, 193 (2026). https://doi.org/10.1038/s41392-026-02735-z
Regulation of immune checkpoint molecules in cancer immune evasion and therapy
Cansu Eris, Cheng Zu, Yanling Xiao, Michael Platten & Chong Sun
Nat Rev Cancer (2026). https://doi.org/10.1038/s41568-026-00934-y
Cansu Eris, Cheng Zu, Yanling Xiao, Michael Platten & Chong Sun
Nat Rev Cancer (2026). https://doi.org/10.1038/s41568-026-00934-y
A tissue-intrinsic mechanism sensitizes HIV-1 particles for TLR-triggered innate immune responses
Samy Sid Ahmed, Liv Zimmermann, Andrea Imle, Katrin Wuebben, Nadine Tibroni, Lena Rauch-Wirth, Jan Münch, Petr Chlanda, Frederik Graw & Oliver T. Fackler
Nat Commun 17, 4209 (2026). https://doi.org/10.1038/s41467-026-72586-3
Samy Sid Ahmed, Liv Zimmermann, Andrea Imle, Katrin Wuebben, Nadine Tibroni, Lena Rauch-Wirth, Jan Münch, Petr Chlanda, Frederik Graw & Oliver T. Fackler
Nat Commun 17, 4209 (2026). https://doi.org/10.1038/s41467-026-72586-3
Phage-assisted evolution of allosteric protein switches
Nicholas T. Southern, Anna von Bachmann, Alisa Hovsepyan, Marielouise Griebl, Benedict Wolf, Nina Lemmen, Ann-Sophie Kroell, Simon Westermann, Jan Mathony & Dominik Niopek
Nat Commun 17, 3498 (2026). https://doi.org/10.1038/s41467-026-71717-0
Nicholas T. Southern, Anna von Bachmann, Alisa Hovsepyan, Marielouise Griebl, Benedict Wolf, Nina Lemmen, Ann-Sophie Kroell, Simon Westermann, Jan Mathony & Dominik Niopek
Nat Commun 17, 3498 (2026). https://doi.org/10.1038/s41467-026-71717-0
Programmable Edge-to-Edge Assembly of RNA Nanostructures
Cody Geary, Mai P. Tran, Erik Poppleton, Alena Taskina, Kerstin Göpfrich
bioRxiv 2026.03.29.714238; doi: https://doi.org/10.64898/2026.03.29.714238
Cody Geary, Mai P. Tran, Erik Poppleton, Alena Taskina, Kerstin Göpfrich
bioRxiv 2026.03.29.714238; doi: https://doi.org/10.64898/2026.03.29.714238
Volume and surface methods for microparticle traction force microscopy: a computational and experimental comparison
Simon Brauburger, Bastian K. Kraus, Tobias Walther, Cornelis Mense, Tobias Abele, Kerstin Göpfrich, Ulrich S. Schwarz
Soft Matter 2026; https://doi.org/10.1039/d6sm00242k
Simon Brauburger, Bastian K. Kraus, Tobias Walther, Cornelis Mense, Tobias Abele, Kerstin Göpfrich, Ulrich S. Schwarz
Soft Matter 2026; https://doi.org/10.1039/d6sm00242k
Buoyancy-driven sorting of synthetic cells for nanopore activity
Maja Lehr, Mattea Unger, Tobias Abele, Stefan J. Maurer, Dirk Flemming, Kerstin Göpfrich
bioRxiv 2026.02.03.702772. doi: https://doi.org/10.64898/2026.02.03.702772
Maja Lehr, Mattea Unger, Tobias Abele, Stefan J. Maurer, Dirk Flemming, Kerstin Göpfrich
bioRxiv 2026.02.03.702772. doi: https://doi.org/10.64898/2026.02.03.702772
Bioswitches: Towards programmable, on-demand control of therapeutic proteins.
Benedict Wolf, Jan Mathony, Dominik Niopek
Clin Transl Med. 2026;16(2):e70612. doi:10.1002/ctm2.70612
Benedict Wolf, Jan Mathony, Dominik Niopek
Clin Transl Med. 2026;16(2):e70612. doi:10.1002/ctm2.70612
2024
Bottom-up synthetic immunology
Kerstin Göpfrich, Michael Platten, Friedrich Frischknecht & Oliver T. Fackler
Nat. Nanotechnol. 19, 1587–1596 (2024). https://doi.org/10.1038/s41565-024-01744-9
Kerstin Göpfrich, Michael Platten, Friedrich Frischknecht & Oliver T. Fackler
Nat. Nanotechnol. 19, 1587–1596 (2024). https://doi.org/10.1038/s41565-024-01744-9
